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Analgesic efficacy of the hydrocodone with ibuprofen combination in contrast with ibuprofen by itself for your remedy of acute postoperative discomfort.[J Clin Pharmacol. 1997]It is not safe to use much more than four grams (4,000 milligrams) of acetaminophen in in the future (24 hours), as this could enhance the hazard for severe liver complicatio